About the Hancock Lab
The Hancock Lab is dedicated to elucidating the underlying mechanisms of motor proteins, kinesin and dynein, that contribute to cell function. By studying the kinetic rates of KIF1A’s transition states, Dr. William O. Hancock and team were able to biochemically characterize the KIF1A chemomechanical cycle. Additionally, the Hancock Lab proposes a mechanistic explanation for KIF1A’s superprocessivity and high velocity by defining the order of states in its chemomechanical cycle and quantifying the transition rates between the states, giving more insight on KIF1A’s evolved and diverse mechanochemistry.
