About the Gennerich Lab
Integrating molecular biology and biochemistry with single-molecule biophysics, the Gennerich Lab seeks to understand the complex mechanisms responsible for intracellular organelle transport, cell division, and protein expression. Dr. Arne Gennerich, widely known for his work with molecular motors and their respective force productions, and his team use multidisciplinary approaches, such as single-molecule assays and optical trapping, to investigate the fundamental mechanisms of the microtubule-associated motor proteins, kinesin and dynein. Regarding KIF1A, the Gennerich Lab’s most recent findings show that KIF1A exhibits force-dependent detachments that result in a unique pattern of highly clustered force generation events. Additionally, their work highlights the important roles the neck-linker and the class-specific “K-loop” play in generating force for kinesin-3 motors, which gives insight on how mutations in this region can lead to human disease.
